Table 5

Phenotypic characterizzation of MM-B1 and IST-Mes3 cells after orthotopic implantation in nude mice.


Cell lines


Marker
IST-Mes3
MM-B1

CEA
-
-
Calretinin
+
+
CD15 (LeuM1)
-
-
Ber-EP4
-
-
Cytokeratin 8/18
+
+
EMA
+ (membrane)
+ (membrane)
HBME-1
+
+
Podoplanin
+
+

IST-Mes3 and MM-B1 cells were injected into the pleural cavity of nude mice. At indicated times the mice were sacrificed and tumor nodules were removed and frozen for immunohistochemical analysis of mesothelioma-specific markers.

Martarelli et al. BMC Cancer 2006 6:130   doi:10.1186/1471-2407-6-130