Table 5

Estimated odds-ratios (ORs) and 95% confidence intervals (CIs) associated with the genotype combinations of the four significant two-way SNP-SNP interactions.

SNP-SNP interaction

SNP Genotypes

Cases n

Controls n

OR^†

95% CI^†

XPD

IL10

XPD-[Lys751Gln] and IL10-[G(-1082)A]

AA

AA

40

57

1.0

-

AC

AA

45

39

1.7

[0.9–2.7]

CC

AA

21

8

3.7

[1.6–9.7]

AA

AG

74

89

1.2

[0.8–1.9]

AC

AG

99

71

1.9

[1.3–3.1]

CC

AG

22

22

1.4

[0.8–3.1]

AA

GG

41

26

2.2

[1.3–3.9]

AC

GG

42

50

1.2

[0.7–2.4]

CC

GG

14

10

2.2

[0.8–5.5]

BARD1

XPD

BARD1-[Pro24Ser] and XPD-[Lys751Gln]

CC

AA

66

60

1.0

-

CT

AA

68

90

0.7

[0.4–1.1]

TT

AA

21

22

0.9

[0.4–1.8]

CC

AC

82

67

1.1

[0.7–1.8]

CT

AC

89

69

1.2

[0.7–1.9]

TT

AC

15

24

0.6

[0.3–1.2]

CC

CC

23

13

1.6

[0.7–3.4]

CT

CC

27

26

1.0

[0.5–1.9]

TT

CC

7

1

7.4

[1.3–12.4]

COMT

CCND1

COMT-[Met108/158Val] and CCND1-[Pro241Pro]

AA

GG

21

40

1.0

-

AG

GG

57

53

1.9

[1.3–4.6]

GG

GG

25

21

2.4

[1.0–4.9]

AA

AG

48

36

2.6

[1.3–4.5]

AG

AG

110

92

2.3

[1.3–4.5]

GG

AG

38

45

1.6

[1.0–3.2]

AA

AA

22

29

1.4

[0.7–3.3]

AG

AA

43

37

2.2

[1.1–4.3]

GG

AA

34

19

3.3

[1.9–7.2]

GSTP1

COMT

GSTP1-[Ile105Val] and COMT-[Met108/158Val]

AA

AA

30

49

1.0

-

AG

AA

46

48

1.5

[0.9–2.8]

GG

AA

15

8

3.4

[1.1–11.4]

AA

AG

95

92

1.7

[1.0–2.6]

AG

AG

91

69

2.2

[1.4–3.6]

GG

AG

24

21

1.8

[0.9–4.8]

AA

GG

54

36

2.6

[1.4–4.2]

AG

GG

36

41

1.5

[0.9–2.7]

GG

GG

7

8

1.6

[0.5–4.2]

^†OR and CIs estimated by bootstrap analysis in the 1,000 random samples.

Onay et al. BMC Cancer 2006 6:114   doi:10.1186/1471-2407-6-114