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Open Access Technical advance

Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports

Georg Seifert1*, Hanno Riess2, Karl Seeger1, Guenter Henze1 and Anja Borgmann1

Author Affiliations

1 Department of Paediatric Oncology/Haematology, Charité – Universitätsmedizin Berlin, Germany

2 Department of Haematology and Oncology, Charité – Universitätsmedizin Berlin, Germany

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BMC Cancer 2006, 6:103  doi:10.1186/1471-2407-6-103

Published: 24 April 2006

Abstract

Background

Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen.

Methods

As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated.

Results

All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma.

Conclusion

Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.