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Open Access Highly Accessed Research article

Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity

Thomas Fillies1*, Richard Werkmeister2, Jens Packeisen3, Burkhard Brandt4, Philippe Morin5, Dieter Weingart5, Ulrich Joos1 and Horst Buerger6

Author Affiliations

1 Department of Cranio-Maxillofacial Surgery, University of Muenster, Waldeyerstrasse 30, 48129 Muenster, Germany

2 Department of Oral and Maxillofacial Surgery, Central German Armed Forces Hospital, Rübenacher Str. 170, 56072 Koblenz, Germany

3 Institute of Pathology, Klinikum Osnabrueck, Germany

4 Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20146 Hamburg, Germany

5 Department of Maxillofacial Surgery, Katharinenhospital Stuttgart, Kriegsbergstrasse 60, 70174 Stuttgart, Germany

6 Institute of Pathology, University of Muenster, Domagkstraβe 17, 48149 Muenster, Germany

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BMC Cancer 2006, 6:10  doi:10.1186/1471-2407-6-10

Published: 13 January 2006

Abstract

Background

Intermediary filaments are involved in cell motility and cancer progression. In a variety of organs, the expression of distinct intermediary filaments are associated with patient prognosis. In this study, we seeked to define the prognostic potential of cytokeratin and vimentin expression patterns in squamous cell carcinomas (SCC's) of the oral cavity.

Methods

308 patients with histologically proven and surgically treated squamous cell carcinomas of the oral cavity were investigated for the immunohistochemical expression of a variety of intermediary filaments including high- and low-molecular weight cytokeratins (Ck's), such as Ck 5/6, Ck 8/18, Ck 1, CK 10, Ck 14, Ck 19 and vimentin, using the tissue microarray technique. Correlations between clinical features and the expression of Cytokeratins and vimentin were evaluated statistically by Kaplan-Meier curves and multivariate Cox regression analysis.

Results

The expression of Ck 8/18 and Ck 19 were overall significantly correlated with a poor clinical prognosis (Ck 8/18 p = 0.04; Ck19 p < 0.01). These findings could also be reproduced for Ck 8/18 in primary nodal-negative SCC's and held true in multivariate-analysis. No significant correlation with patient prognosis could be found for the expression of the other cytokeratins and for vimentin.

Conclusion

The expression of Ck 8/18 in SCC's of the oral cavity is an independent prognostic marker and indicates a decreased overall and progression free survival. These results provide an extended knowledge about the role of intermediary filament expression patterns in SCC's.