Table 3 |
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|
Selected highly expressed genes in grade III and IV astrocytomas. |
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|
Tag Sequence |
Tumora |
Inductionb |
Gene |
Gene Ontology |
|
|
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|
Anaplastic astrocytomas (Grade III) |
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|
AAGCCGAAGA |
10 |
40 |
GFAP glial fibrillary acidic protein |
Major intermediate filament protein of mature astrocytes |
|
CTGGGGAGTG |
8.1 |
22 |
VAPB VAMP associated protein B and C |
Type IV membrane protein in plasma and intracellular vesicle membranes |
|
GCAACAGCAA |
80.9 |
19 |
SEC61G Sec61 gamma subunit |
Endoplasmatic reticulum membrane protein, translocation |
|
TTAATCTGAG |
6.9 |
18 |
ARHGEF6 |
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6, intra-cellular |
|
ATCTTGTTAC |
11 |
15 |
FN1 fibronectin 1 |
Extra-cellular matrix, cell adhesion, cell migration |
|
GGAACAAACA |
11.9 |
14 |
CD24 |
Plasma membrane, small cell lung carcinoma cluster 4 antigen |
|
AGGGAGGGGC |
32.9 |
14 |
GPX3 glutathione peroxidase 3 |
Extra-cellular, response to oxidative stress, glutathione metabolism |
|
GTATGGGCCC |
26.8 |
13 |
CHI3L1 chitinase 3-like 1 |
Cartilage glycoprotein |
|
ACGAGGGGTG |
71.4 |
12 |
BCAN, chondroitin sulfate proteoglycan |
Cell adhesion |
|
CACTTGAAAA |
6.9 |
11 |
CALU calumenin |
Endoplasmatic reticulum, calcium ion binding |
|
GATAACTACA |
6.7 |
11 |
IGFBP7 |
Extra-cellular, insulin-like growth factor binding protein 7 |
|
TCCTGTAAAG |
6.8 |
11 |
CAV1 caveolin 1, 22 kDa |
Plasma membrane, caveolae protein, integrin-mediated celladhesion, vesicular trafficking |
|
GTCTTAAAGT |
41.8 |
10 |
SOD2 |
Superoxide dismutase, mitochondrial, erythropoietin-mediated neuro protection through NF-kB |
|
Glioblastomas (grade IV) |
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|
GTATGGGCCC |
144.2 |
72 |
CHI3L1 chitinase 3-like 1 |
Cartilage glycoprotein |
|
GACCACCTTT |
17.3 |
69 |
MFAP2 microfibrillar-associated protein 2 |
Major antigen of elastin-associated microfibrils |
|
ACCAAAAACC |
115.8 |
49 |
COL1A1 collagen, type I, alpha 1 |
Extra-cellular matrix |
|
AGTGGTGGCT |
14.8 |
39 |
FMOD fibromodulin |
Extra-cellular matrix, TGF beta receptor complex assembly |
|
CTGGGGAGTG |
13.2 |
35 |
VAPB VAMP associated protein B and C |
Type IV membrane protein in plasma and intracellular vesicle membranes |
|
ACATTCTTTT |
38.2 |
34 |
GPNMB glycoprotein nmb |
Transmembrane glycoprotein |
|
ATCTTGTTAC |
21.1 |
28 |
FN1 fibronectin 1 |
Extra-cellular matrix, cell adhesion, cell migration |
|
GCAACAGCAA |
97.9 |
23 |
SEC61G Sec61 gamma subunit |
Endoplasmatic reticulum membrane protein, translocation |
|
TCACCAAAAA |
19.3 |
19 |
STAB1 stabilin 1 |
Cell adhesion, calcium ion binding |
|
CACTTGAAAA |
11.6 |
19 |
CALU calumenin |
Endoplasmatic reticulum, calcium ion binding |
|
TTTTCAAATA |
15.4 |
15 |
T1A-2 lung type-I |
Type I integral membrane glycoprotein |
|
GTCTTTCTTG |
24.4 |
14 |
RAB13 |
Cell adhesion, member RAS oncogene family |
|
GGAAATGTCA |
12.6 |
13 |
MMP2 matrix metalloproteinase |
Extra-cellular matrix, calcium ion binding |
|
GTACTAGTGT |
23.8 |
12 |
CCL2 chemokine (C-C motif) ligand 2 |
Extra-cellular matrix, cell adhesion, signal transduction |
|
AAGCTGTATA |
16.7 |
12 |
TNC tenascin C (hexabrachion) |
Extra-cellular matrix, cell adhesion |
|
GTGCTAAGCG |
10.8 |
11 |
COL6A2 collagen, type VI, alpha 2 |
Extra-cellular matrix |
|
CATATCATTA |
151.6 |
11 |
IGFBP7 |
Extra-cellular, insulin-like growth factor binding protein 7 |
|
AACACAGCCT |
24.9 |
11 |
C4A complement component 4A |
Extra-cellular matrix, complement pathway |
|
|
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|
Highly expressed genes were selected with at least a ten fold over-expression when compared to normal neural tissue and a minimal expression level of at least 5 or 10 counts per 100,000 tags (in respectively grade III and IV tumors) in 30% of the corresponding tumor type. aAverage tag count count per individaul tunor SAGE library. bAverage induction factor. |
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|
Boon et al. BMC Cancer 2004 4:39 doi:10.1186/1471-2407-4-39 |
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