Table 4

Risk of lung cancer in association with aspirin use among current and former smokers – Effect of packyears of cigarettes smoked – Roswell Park Cancer Institute, 1982–1998.

Lower tertile of packyear distribution

(1 – 34 packyears)

Middle tertile of packyear distribution

(34.1 – 60 packyears)

Upper tertile of packyear distribution

(60.1 – 260 packyears)




Cases

(n = 162)

Controls

(n = 288)

Adjusted OR1

(95% CI)

Cases

(n = 307)

Controls

(n = 157)

Adjusted OR1

(95% CI)

Cases

(n = 336)

Controls

(n = 90)

Adjusted OR1

(95% CI)


Non-User

149

238

1.0

264

127

1.0

278

68

1.0

Regular User2

13

50

0.43 (0.22–0.83)

43

30

0.70 (0.41–1.18)

58

22

0.66 (0.37–1.16)

1–6 tablets/week

2

10

0.32 (0.07–1.53)

7

5

0.62 (0.19–2.05)

16

2

2.02 (0.45–9.04)

7+ tablets/week

11

40

0.45 (0.22–0.92)

36

25

0.71 (0.40–1.26)

42

20

0.52 (0.28–0.95)

p = 0.02

p = 0.20

p = 0.06

1–10 years of use

10

35

0.47 (0.22–0.99)

33

23

0.66 (0.37–1.19)

44

16

0.68 (0.36–1.29)

11+ years of use

3

15

0.32 (0.09–1.16)

10

7

0.83 (0.30–2.29)

14

6

0.59 (0.22–1.61)

p = 0.01

p = 0.26

p = 0.15

1–10 tablet years3

10

27

0.60 (0.28–1.30)

33

22

0.70 (0.38–1.26)

38

12

0.78 (0.38–1.58)

11+ tablet years

3

23

0.22 (0.06–0.75)

10

8

0.70 (0.26–1.86)

20

10

0.51 (0.22–1.15)

p = 0.006

p = 0.21

p = 0.09


1 Odds ratio adjusted for age and education 2 Regular use was defined as self-reported use at least once a week for at least one year 3 Tablets per day × years of use

Moysich et al. BMC Cancer 2002 2:31   doi:10.1186/1471-2407-2-31

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