Open Access Highly Accessed Research article

TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells

Susann Voigt1, Stephan Philipp1, Parvin Davarnia1, Supandi Winoto-Morbach1, Christian Röder2, Christoph Arenz3, Anna Trauzold2, Dieter Kabelitz1, Stefan Schütze1, Holger Kalthoff2 and Dieter Adam1*

Author Affiliations

1 Institut für Immunologie, Christian-Albrechts-Universität, Michaelisstrasse 5, 24105 Kiel, Germany

2 Sektion für Molekulare Onkologie, Institut für Experimentelle Tumorforschung, Christian-Albrechts-Universität, Kiel, Germany

3 Institut für Chemie der Humboldt-Universität, Berlin, Germany

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BMC Cancer 2014, 14:74  doi:10.1186/1471-2407-14-74

Published: 7 February 2014

Additional files

Additional file 1: Figure S1a:

Treatment with TRAIL/zVAD/CHX or TNF/zVAD/CHX does not elicit caspase-dependent apoptosis in tumor cells.

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Additional file 2: Figure S1b:

Treatment with TRAIL/zVAD/CHX or TNF/zVAD/CHX does not elicit caspase-dependent apoptosis in tumor cells.

Format: TIF Size: 18.9MB Download file

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Additional file 3: Figure S1c:

and Figure S1d. Treatment with TRAIL/zVAD/CHX or TNF/zVAD/CHX does not elicit caspase-dependent apoptosis in tumor cells.

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Additional file 4: Figure S2:

Role of RIPK1 and RIPK3 as determinants of susceptibility or resistance of tumor cell lines to programmed necrosis.

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