Blood transcript analysis and metastatic recurrent small bowel carcinoid management
1 Wren Laboratories, 35 NE Industrial Road, Branford, CT 06405, USA
2 Bering Limited, Richmond, UK
3 Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy
4 Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
BMC Cancer 2014, 14:564 doi:10.1186/1471-2407-14-564Published: 5 August 2014
Detection of neuroendocrine tumor (NET) disease progression is a key issue in determining management. Currently, assessment is by imaging (MRI/CT and Octreoscan®) and plasma Chromogranin A (CgA) measurement.
We report use of a NET-specific multigene PCR-derived blood transcript signature (NET Index) to assess disease and correlated CgA and gene transcripts with MRI, CT, Octreoscan®, 11C-5HTP-PET/CT and 68Ga-DOTA-PET/CT in a patient with NET.
Our results identify limitations in evaluating disease status by CgA and identify that a PCR-based test is more sensitive. Alteration in NET blood gene transcript levels prior to image-based tumor confirmation suggests this parameter may also have utility as an index of therapeutic efficacy.