Open Access Highly Accessed Research article

Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling

María D Cuenca-López1, Juan C Montero2, Jorge C Morales1, Aleix Prat3, Atanasio Pandiella2 and Alberto Ocana1*

Author Affiliations

1 Translational Cancer Research Unit, Albacete University Hospital, 02006 Albacete, Spain

2 Salamanca Cancer Research Center-CSIC, Salamanca, Spain

3 Vall D’Hebron Institute of Oncology (VHIO), Barcelona, Spain

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BMC Cancer 2014, 14:302  doi:10.1186/1471-2407-14-302

Published: 30 April 2014

Additional files

Additional file 1: Figure S1:

Human Phospho Kinase Array kit including Receptor Tysosine Kinases and downstream proteins in human samples from triple negative breast cancer patients. Lower pannels describe the exact possition of each protein in duplicate. For more details see the Methods section.

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Additional file 2: Figure S2:

Relationship between pAKTS473, pAKTS308, pErk1/2 and AR expression in human samples using data from the kinase arrays. AR expression was measured by western blot (as described in Figure 1) and classified in two groups: negative or positive. Lower paneel shows three representative examples of human patients where pAKT and pErk1/2 was activated.

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