Email updates

Keep up to date with the latest news and content from BMC Cancer and BioMed Central.

Open Access Highly Accessed Research article

A retrospective analysis of survival and prognostic factors of male breast cancer from a single center

Amr A Soliman1*, Adel T Denewer2, Wael El-Sadda3, Ali H Abdel-Aty3 and Basel Refky2

Author Affiliations

1 Department of Obstetrics and Gynecology, El-Shatby Maternity University Hospital, University of Alexandria, Port Said Street, El Shatby, Alexandria 21526, Egypt

2 Department of Surgical Oncology, Mansoura Cancer Center, Mansoura 35511, Egypt

3 Department of Nuclear Medicine, Mansoura Cancer Center, Mansoura 35511, Egypt

For all author emails, please log on.

BMC Cancer 2014, 14:227  doi:10.1186/1471-2407-14-227

Published: 28 March 2014

Abstract

Background

Less than 1% of all breast cancer cases are found in men, who reportedly have inferior outcomes compared with matched women patients. Ethnic differences may also affect their prognosis. Here, we investigated overall survival (OS) and major prognostic factors for male breast cancer (MBC) in a cohort of Egyptian patients.

Methods

We retrospectively analyzed OS in a cohort of 69 male patients with MBC who were surgically treated at the Mansoura Cancer Center, Egypt between 2000 and 2007. We registered demographic data, age, height, weight and body mass index, tumor size, histology, number of infiltrated axillary lymph nodes, hormone receptor (HR) status and metastatic presence, and TNM staging. Patients’ OS was the primary endpoint. Patients received treatment to the medical standards at the time of their diagnosis.

Results

In the 69 patients who met the inclusion criteria and had complete stored patient data, tumors ranged from T1c to T3. We could gather cancer-related survival data from only 56 patients. The collective 5-year survival in this cohort was 46.4%. Only five patients had distant metastasis at diagnosis, but they showed a null percent 5-year survival, whereas those with no lymph node infiltration showed a 100% 5-year survival. Lymph node status and tumor grading were the only prognostic factors that significantly affected OS.

Conclusions

Lymph node status and tumor grade are the most important prognostic factors for overall survival of MBC in Egyptian male patients; whereas even remarkably low HR expression in MBC did not significantly affect OS. Further research is needed to understand the factors that affect this disease.

Keywords:
Male breast cancer; Overall survival; Prognostic factors; Hormone receptor status