Table 6

Surgical results and overall response
Dose level
1 2 3 Total
Number of patients 4 (100%) 13 (100%) 7 (100%) 24 (100%)
Surgery?
  No 1 (25%) 2 (15%) 3 (43%) 6 (25%)
  Yes 3 (75%) 11 (85%) 4 (57%) 18 (75%)
If so:
  R0 2 (67%) 8 (73%) 4 (100%) 14 (78%)
Grading
  G2 3 (27%) 1 (25%) 4 (22%)
  G3 2 (67%) 4 (36%) 2 (50%) 8 (44%)
  Information missing 1 (33%) 4 (36%) 1 (25%) 6 (33%)
Response prior to surgery (RECIST)
  N 3 (100%) 12 (100%) 7 (100%) 22 (100%)
  PR 2 (67%) 3 (25%) 2 (29%) 7 (32%)
  SD 5 (42%) 2 (29%) 7 (32%)
  PD 1 (33%) 2 (17%) 2 (29%) 1 (5%)
  NK/ND 2 (17%) 1 (14%) 2 (9%)
Staging prior to surgery (UICC)
  N 4 (100%) 12 (100%) 7 (100%) 23 (100%)
  II A 4 (33%) 1 (14%) 5 (229%)
  II B 1 (8%) 1 (14%) 2 (9%)
  III 3 (75%) 4 (33%) 2 (29%) 9 (39%)
  IV 1 (14%) 1 (4%)
  NK/ND 1 (25%) 3 (25%) 2 (29%) 6 (26%)
Pathologic response [15]
  N 3 (100%) 11 (100%) 4 (100%) 18 (100%)
  CR 4 (36%) 2 (50%) 6 (33%)
  PR 1 (33%) 4 (36%) 2 (50%) 7 (39%)
  SD 1 (9%) 1 (6%)
  PD 1 (33%) 1 (9%) 2 (11%)
  NK/ND 1 (33%) 1 (9%) 2 (11%)
Staging after surgery (UICC)
  N 3 (100%) 11 (100%) 4 (100%) 18 (100%)
  0 2 (18%) 1 (25%) 3 (17%)
  I 1 (9%) 1 (25%) 2 (11%)
  II A 1 (33%) 2 (18%) 3 (17%)
  II B 1 (33%) 2 (18%) 2 (50%) 5 (28%)
  III 1 (9%) 1 (6%)
  NK/ND 1 (33%) 3 (27%) 4 (22%)

Moehler et al.

Moehler et al. BMC Cancer 2013 13:75   doi:10.1186/1471-2407-13-75

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