Table 2

Dose-limiting toxicities per dose level
Dose level
1 2 3 Total
Number of patients 4 (100%) 13 (100%) 7 (100%) 24 (100%)
Any DLTs?
  No 3 (75%) 12 (92%) 2 (29%) 17 (71%)
  Yes 1 (25%) 1 (8%) 5 (71%) 7 (29%)
If yes:
CTC-Grade III IV III IV III IV
Non-haematological toxicity grade ≥ 3: 6 (25%)
 - Dehydration, syncope 1
 - Heartburn/dyspepsia 1
 - Fatigue 2
 - Diarrhea 1
 - Infection 1
Haematological toxicity: 1 (4%)
 - Thrombocytpenia 1

DLT, dose limiting toxicity.

Moehler et al.

Moehler et al. BMC Cancer 2013 13:75   doi:10.1186/1471-2407-13-75

Open Data