Table 2

Clinicopahtological characteristics of patients grouped according to mGPS
Variable mGPS 0 (n = 119) mGPS 1 (n = 11) mGPS 2 (n = 20) P-value
Age (years) 72 (43–91) 74 (64–82) 72 (51–79) 0.14
Sex (male/female) 80/39 10/1 16/4 0.16
HBsAg positive (%) 12 (10) 2 (18) 5 (25) 0.15
HCVAb positive (%) 76 (64) 1 (9) 7 (35) 0
AST (IU/l) 53 (14–240) 56 (17–238) 113 (13–384) <0.0001
ALT (IU/l) 39 (10–202) 53 (14–190) 78 (8–157) 0.02
Total serum bilirubin (mg/dl) 0.8 (0.3-3.1) 0.7 (0.3-6.1) 1.6 (0.3-8.3) 0
Albumin (g/dl) 3.7 (2.1-5) 3.9 (3.5-4.6) 3.2 (2.2-3.4) <0.0001
CRP (mg/dl) 0.1 (0.1-0.9) 1.5 (1.1-2.9) 2.6 (1.1-18.8) <0.0001
WBC (cells/mm3 ) 5200 (1800–14900) 5900 (3500–10600) 5800 (3900–12400) 0.07
Platelet count (104/mm3 ) 13.2 (2.8-30.9) 25.3 (1.8-42.1) 17.3 (8.7-44.3) 0
Prothrombin time (%) 83 (38–100) 95 (74–100) 77 (45–97) 0.01
α-fetoprotein (ng/ml) 22 (1.9-59597) 77 (2–138011) 144 (1.7-280600) 0.05
Child-Pugh grade (A/B/C) 91/26/2 10/1/0 6/10/4 <0.0001
CLIP score (0/1/2/3≧) 41/43/24/11 3/0/3/5 0/7/1/12 <0.0001
JIS score (0/1/2/3≧) 18/43/41/17 0/4/3/4 0/1/6/13 <0.0001
BCLC score (0/A/B/C,D) 18/61/31/9 0/4/2/5 0/6/2/12 <0.0001
Tumor stage (І,ІІ,ІІІ,ІV) 21/52/41/5 0/4/3/4 1/4/4/11 <0.0001
Maximal tumor diameter (mm) 30 (7–200) 110 (40–150) 50 (10–130) <0.0001
Tumor number (solitary/multiple) 66/53 6/5 5/15 0.04
Vascular invasion (absent/present) 114/5 8/3 13/7 <0.0001
Extrahepatic metastasis (absent/present) 117/2 10/1 17/3 0.01

Abbreviaions: HBsAg = hepatitis B surface antigen; HCVAb = hepatitis C antibody; AST = aspartate aminotransferase; ALT = alanine aminotransferase.

CRP = C-reactive protein; WBC = white blood cell count; ICG = indocyanine green dye retention rate at 15 minutes; CLIP = Cancer of the Liver Italian Program.

JIS = Japan Integrated Staging score; BCLC = Barcelona Clinic Liver Cancer; GPS = Glasgow Prognostic Score.

Kinoshita et al.

Kinoshita et al. BMC Cancer 2013 13:52   doi:10.1186/1471-2407-13-52

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