Sirt1 expression in PDAC. A) (overview, x5) and B (x20) show nuclear Sirt localization with a weak staining signal. C) (overview, x5) and D (x20) display a strong nuclear Sirt1 immunosignal. E) Kaplan-Meier curve for postsurgical survival according to Sirt1 expression. The given p-value was calculated in a log-rank test. The red line indicates tumors of patients with high Sirt1 expression whereas the blue line indicates those with low Sirt1 expression.
Stenzinger et al. BMC Cancer 2013 13:450 doi:10.1186/1471-2407-13-450