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Open Access Research article

The relationship of Vascular endothelial growth factor gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX: VEGF polymorphism in gastric cancer

Sung Yong Oh1, Hyuk-Chan Kwon1, Sung Hyun Kim1, Suee Lee1, Ji Hyun Lee1, Jung-Ah Hwang2, Seung Hyun Hong2, Christian A Graves3, Kevin Camphausen3, Hyo-Jin Kim1 and Yeon-Su Lee2*

Author Affiliations

1 Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea

2 Cancer Genomics Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi-do, 410-769, Korea

3 Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA

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BMC Cancer 2013, 13:43  doi:10.1186/1471-2407-13-43

Published: 1 February 2013

Abstract

Background

The aim of this study is to evaluate the associations between vascular endothelial growth factor (VEGF) Single-nucleotide polymorphisms (SNPs) and clinical outcome in advanced gastric cancer patients treated with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX).

Methods

Genomic DNA was isolated from whole blood, and six VEGF (−2578C/A, -2489C/T, -1498 T/C, -634 G/C, +936C/T, and +1612 G/A) gene polymorphisms were analyzed by PCR. Levels of serum VEGF were measured using enzyme-linked immunoassays.

Results

Patients with G/G genotype for VEGF -634 G/C gene polymorphism showed a lower response rate (22.2%) than those with G/C or C/C genotype (32.3%, 51.1%; P = 0.034). Patients with the VEGF -634 G/C polymorphism G/C + C/C genotype had a longer progression free survival (PFS) of 4.9 months, compared with the PFS of 3.5 months for those with the G/G (P = 0.043, log-rank test). By multivariate analysis, this G/G genotype of VEGF -634 G/C polymorphism was identified as an independent prognostic factor (Hazard ratio 1.497, P = 0.017).

Conclusion

Our data suggest that G/G genotype of VEGF -634 G/C polymorphism is related to the higher serum levels of VEGF, and poor clinical outcome in advanced gastric cancer patients.

Keywords:
VEGF; Polymorphism; Gastric cancer