Administration of APMS-MB-DOX microparticles (0.05 mg/kg) enhances cell death in spheroid tumors. Paraffin sections (4 μm thick) of mesenteric and spheroid MM tumors from each animal were stained using H&E. (A) Quantification of the average percent necrosis (Mean +/- SEM) per area of section was assessed by a board-certified pathologist analyzing 4 fields at 10× magnification. Trends in mesenteric tumors did not reach statistical significance. (B) Representative images of both mesenteric and spheroid tumors; scale bar represents 100 μM. N = necrotic area.
Macura et al. BMC Cancer 2013 13:400 doi:10.1186/1471-2407-13-400