|Concentration of cytokines in tumors 5 days after the combined modality treatment|
|Control groups||< 330 pg/g||< 2820 pg/g|
|EGT mIL-12||1027 ± 400 pg/g *||6509 ± 1018 pg/g *|
|EGT mIL-12 + IR||1671 ± 529 pg/g *||7191 ± 1283 pg/g *|
Therapeutic groups: mIL-12 gene electrotransfer alone (EGT mIL-12) or combined with tumor irradiation (EGT mIL-12 + IR). Control groups are untreated control, 10 Gy single dose irradiation (IR), electrical pulse application alone (EP) or combined with irradiation (EP + IR), intratumoral injection of plasmid DNA coding for mIL-12 or dsRed alone (mIL-12, dsRed) or combined with irradiation (mIL-12 + IR, dsRed + IR), dsRed gene electrotransfer alone (EGT dsRed) or combined with irradiation (EGT dsRed + IR).
mIL-12 – intratumoral levels of mIL-12.
mIFNγ – intratumoral levels of mIFNγ.
* Statistically significant difference compared to untreated control (p < 0.05).
Number of animals in control groups was 8 – 9. Number of animals in groups EGT mIL-12 and EGT mIL-12 + IR was pooled from two experiments and was 17–18.
Sedlar et al.
Sedlar et al. BMC Cancer 2013 13:38 doi:10.1186/1471-2407-13-38