Size of osteolytic lesions (mm2)in nude mice with bone metastases. Osteolytic lesions were analysed by plain radiography 5 weeks following tumor cell inoculation; Control (n = 7), Sunitinib (n = 7). Box plot shows 25–75 percentiles, whiskers 05–95 percentiles,+ indicates mean and line indicates median. Significance was determined by 2-tailed Student t-test (*p < 0.05, op < 0.1). No difference is observed in the size of osteolytic lesions with Sunitinib therapy (mean ± SD: Ctrl 0.65 ± 0.33; Sunitinib 0.59 ±0.35).
Schem et al. BMC Cancer 2013 13:32 doi:10.1186/1471-2407-13-32