Open Access Highly Accessed Research article

Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents

Hiu-Ying Lau14, Chit-Ming Leung14, Yap-Hang Chan145*, Anne Wing-Mui Lee34, Dora Lai-Wan Kwong24, Maria Li Lung24 and Tai-Hing Lam14

Author Affiliations

1 School of Public Health, University of Hong Kong, Hong Kong, China

2 Department of Clinical Oncology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China

3 Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong

4 Epidemiology Group, Center for Nasopharyngeal Carcinoma Research, Hong Kong RGC Area of Excellence Scheme, Hong Kong, China

5 School of Public Health, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China

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BMC Cancer 2013, 13:298  doi:10.1186/1471-2407-13-298

Published: 19 June 2013

Abstract

Background

Despite salted fish being a classical risk factor of Nasopharyngeal Carcinoma (NPC), whether secular trends in salted fish consumption worldwide accounted for changes in NPC rates were unknown. The relationship between vegetable and cigarette consumption to NPC risk worldwide were also largely uncertain. We investigated the longitudinal trends in standardised NPC incidence/mortality rates across 8 regions and their associations with secular trends in salted fish, vegetable and tobacco consumptions.

Methods

Age standardised mortality rate (ASMR) and age standardised incidence rate (ASIR) of NPC were obtained from the WHO cancer mortality database and Hong Kong Cancer Registry. Per capita consumption of salted fish, tobacco and vegetables in Hong Kong and 7 countries (China, Finland, Japan, Portugal, Singapore, United Kingdom and United States) were obtained from the Food and Agriculture Organization of the United Nation (FAO) and Hong Kong Trade and Census Statistics. Pearson correlation and multivariate analysis were performed to examine both crude and adjusted associations.

Results

There were markedly decreasing trends of NPC ASIR and ASMR in Hong Kong over the past three decades, which were correlated with corresponding secular changes in salted fish consumption per capita (Pearson r for 10 cumulative years : ASIR = 0.729 (male), 0.674 (female); ASMR = 0.943 (male), 0.622 (female), all p < 0.05 except for female ASMR). However such associations no longer correlated with adjustments for decreasing tobacco and increasing vegetable consumption per capita (Pearson r for 10 cumulative years: ASIR = 2.007 (male), 0.339 (female), ASMR = 0.289 (male), 1.992 (female), all p > 0.05). However, there were no clear or consistent patterns in relations between NPC ASIR and ASMR with salted fish consumption across 7 regions in 3 continents.

Conclusions

Our results do not support the notion that changes in salted fish consumption had played an important role in explaining secular trends of NPC rates in Hong Kong and worldwide. Further studies should explore other lifestyle and genetic factors. However, our findings do support the potentially protective effects of vegetable consumption against NPC.

Keywords:
Nasopharyngeal carcinoma; Salted fish consumption; Tobacco; Secular trend; Ecological study