Table 1

Overview of OCAC studies
Study acronym Study name Controls, n Cases, n White non-Hispanic %* Carcinoma cases with grade information % Recruitment year and location Matching variables
Border-line All carcinomas§ Serous Muc-inous Endo-metrioid Clear Cell
AUS [59] AOCS (Australian Ovarian Cancer Study) and ACS (Australian Cancer Study – Ovarian Cancer) 1,333 259 882 537 39 106 71 93.3 92.8 2002-2006; Australia State of residence and 5-year age groups
CON [43] CON (Connecticut Ovarian Cancer Study) 526 103 339 193 18 70 33 91.7 85.4 1998-2003; Connecticut, USA 3 age strata (35-49, 50-64 and 65-79 years)
DOV [44] DOVE (Diseases of the Ovary and their Evaluation) 1,116 189 483 269 20 81 31 90.9 82.7 2002-2005 and 2006-2009; Washington, USA 5-year age groups, 1-year calendar intervals and two county strata
GER [54] GOCS (German Ovarian Cancer Study) 502 30 209 107 24 23 6 99.9 100 1993-1996; Germany Age and study region
HAW [45] HAWAII (Hawaii Ovarian Cancer Study) 1,100 97 384 176 42 68 50 31.9 91.3 1993-2008; Hawaii, USA 5-year age groups and race
HOP [46] HOPE (Hormones and Ovarian Cancer Prediction Study) 1,365 76 530 289 27 71 46 96.0 94.1 2003-2009; Pennsylvania, USA 5-year age groups and area code plus 3 number prefix
MAL [55-57] MALOVA (Malignant Ovarian Cancer Study) 908 115 267 157 30 41 21 100 93.9 1994-1999; Denmark 5-year age groups
NCO [47,48] NCOCS (North Carolina Ovarian Cancer Study) 979 212 777 429 44 126 82 80.9 100 1999-2008; North Carolina, USA 5-year age groups and race
NEC [49,50] NECC (New England-based Case-Control Study) 1,109 274 707 386 47 152 96 96.3 100 1992-1997 and 1998-2003; New England, USA 5-year age groups and region of residence
NJO [51,52] NJOCS (New Jersey Ovarian Cancer Study) 277 0 183 104 7 30 24 87.6 87.2 2002-2008; New Jersey, USA None
POL [58] POL (Polish Ovarian Cancer Control Study) 601 18 236 101 25 52 13 100 66.3 2000-2003; Poland 5-year age groups and study center
SON [53] SON (Southern Ontario Study of Reproduction, Diet and Health) 542 82 345 200 38 65 28 98.3 0 1989-1992; Southern Ontario 3 age strata (35-49, 50-64 and 65-79 years)
Totals 10,358 1,455 5,342 2,948 361 885 501 87.7 84.86

* White non-Hispanic subjects as a percentage of all race-ethnicities enrolled in each study.

† Percentages reflect grade available for serous, mucinous and endometrioid carcinomas and for which we applied the algorithm to reduce histologic misclassification (see Methods).

‡ All studies except GER used frequency matching.

§ Includes the epithelial histologic types: serous, mucinous, endometrioid, clear cell, mixed epithelial, transitional cell, squamous cell, and undifferentiated.

Kelemen et al.

Kelemen et al. BMC Cancer 2013 13:28   doi:10.1186/1471-2407-13-28

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