Table 2

Primary information for 7 genotyped SNPs in DNA repair genes
Genotyped SNPs Location/or amino acid change MAF for Chinese in databasea Pvalue for HWE test
XRCC3: rs861539 C>T nsSNP/ T241M 0.067 0.165
XRCC3: rs1799794 G>A 5' UTR 0.478 0.271
XRCC3: rs1799796 A>T nsSNP/ A17893G 0.289 0.406
BRCA2: rs1799943 G>A Promoter 0.279 0.722
BRCA2: rs15869 A>C 3' UTR 0.244 0.375
RAG1: rs2227973 G>A nsSNP/ R820K 0.465 0.586
XRCC5: rs1051685 A>G 3' UTR 0.067 0.808
LIG4: rs1805388 C>T nsSNP/T9I 0.261 0.659
XRCC4: rs1805377 A>G Splice Site 0.300 0.454
ATM: rs189037 G>A Promoter 0.389 0.070

MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium.

aMinor allele frequency in the Chinese (CHB, Han Chinese in Beijing, China) population, as reported in dbSNP database.

Zhao et al.

Zhao et al. BMC Cancer 2013 13:234   doi:10.1186/1471-2407-13-234

Open Data