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Open Access Research article

Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study

Pablo Conesa-Zamora1*, Javier Ruiz-Cosano1, Daniel Torres-Moreno1, Ignacio Español2, María D Gutiérrez-Meca2, Javier Trujillo-Santos3, Elena Pérez-Ceballos4, Rocío González-Conejero5, Javier Corral5, Vicente Vicente4 and Miguel Pérez-Guillermo1

Author Affiliations

1 Molecular Pathology and Pharmacogenetic Group. Pathology Department, Santa Lucía General University Hospital (HGUSL), 30202, Cartagena, Spain

2 Haematology Department. (HGUSL), 30202, Cartagena, Spain

3 Internal Medicine Department. (HGUSL), 30202, Cartagena, Spain

4 Haematology Department, Morales Meseguer University Hospital (HGUMM), Murcia, Spain

5 Department of Medicine, Centro Regional de Hemodonación, 30003, Murcia, Spain

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BMC Cancer 2013, 13:228  doi:10.1186/1471-2407-13-228

Published: 7 May 2013

Abstract

Background

The interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in the detoxification of potential carcinogens.

Methods

We have studied the prevalence of three functional polymorphisms affecting these genes rs1051740 EPHX1, rs1800566 NQO1 and rs662 PON1 in 215 patients with lymphoma and 214 healthy controls.

Results

Genotype frequencies for EPHX and NQO1 polymorphisms did not show any correlation with disease. In contrast, the GG genotype in the PON1 polymorphism was found to be strongly associated with the disease (15.3% vs. 4.7%; OR = 3.7 CI (95%): 1.8-7.7; p < 0.001). According to the pathological diagnosis this association was related to follicular (p = 0.004) and diffuse large B-cell (p = 0.016) lymphomas.

Conclusions

Despite the fact that further confirmation is needed, this study shows that the PON1 GG genotype in rs662 polymorphism could be a risk factor for B-cell lymphomas.

Keywords:
PON1; NQO1; EPHX1; Polymorphism; SNP; Lymphoma; Susceptibility