Effects of oral treatment with imatinib mesylate on tumor growth in mice of the xenograft model. One group of mice was treated with 100 mg/kg/day imatinib mesylate (■; treatment group) while the other was treated with water (○; control group). (A, left) Xenografts were established by injection of HS-Sch-2 cells in female NOD/SCID mice. The tumor volume was significantly smaller in the treatment group than the control (■; n = 5, ○; n = 6, *P < 0.01, by Student’s t-test) on day 28. (B, left) Imatinib mesylate significantly reduced the growth of FMS-1 xenografts compared with the control groups (■; n = 7, ○; n = 6, **P < 0.05, by Student’s t-test). (C, left) Imatinib mesylate did not affect the growth of NMS-2PC xenografts (■; n = 4, ○; n = 4). Representative picture of animals are shown at right for each experiment.
Ohishi et al. BMC Cancer 2013 13:224 doi:10.1186/1471-2407-13-224