Open Access Research article

Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β

Jun Ohishi12, Mikiko Aoki1, Kazuki Nabeshima1*, Junji Suzumiya3, Tamotsu Takeuchi4, Akira Ogose5, Michiyuki Hakozaki6, Yuichi Yamashita2 and Hiroshi Iwasaki1

Author Affiliations

1 Department of Pathology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan

2 Gastroenterological Surgery, Fukuoka University School of Medicine, Fukuoka, Japan

3 Shimane University Hospital Cancer Center, Shimane, Japan

4 Department of Immunopathology, University School of Medicine, Gifu, Japan

5 Division of Orthopaedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medicine and Dental Science, Niigata, Japan

6 Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan

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BMC Cancer 2013, 13:224  doi:10.1186/1471-2407-13-224

Published: 4 May 2013

Additional files

Additional file 1: Figure S1:

During imatinib mesylate treatment, the body weight was only slightly affected, with less than 7% reduction in all mice.

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Additional file 2: Figure S2:

Transplanted tumors showed a proliferation of atypical spindle or polygonal shaped cells with oval nuclei and distinct nucleoli. These cells proliferated loosely as interconnected cords or networks, or compactly in a sheet-like pattern. Mitotic figures are frequently observed. There were no differences in histological findings between the treatment and control groups.

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Additional file 3: Figure S3:

During imatinib mesylate treatment, there were no differences in histological findings of the intestine, spleen, liver, and lungs between the treatment group and the control group.

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Additional file 4: Figure S4:

Using fluorescence in situ hybridization (FISH), we examined whether MPNST cell lines contained fusion genes involving the PDGF-B. No slit of the PDGF-B gene was detected in any of the six MPNST cell lines.

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