Kaplan Meier analysis comparing pathological Gleason score versus Hp1γ. PSA failure after radical prostatectomy was examined in samples stained for Hp1γ. A) Gleason score provides minimal separation of patients into risk categories for biochemical recurrence using a Log rank analysis (P = 0.2). B) Cytoplasmic Hp1γ is superior to pathological Gleason score when Gleason score was stratified into high versus low Hp1γ. The median value for Hp1γ staining in was 3.5 in all benign and cancer samples and this value was subsequently used as a cut point to define high versus low cytoplasmic Hp1γ expression for the Log rank analysis. Hp1γ accurately predict biochemical recurrence within each Gleason category including intermediate grade cancer (GS 6, 7).
Slezak et al. BMC Cancer 2013 13:148 doi:10.1186/1471-2407-13-148