Table 1

Study treatment doses
Phase A Phase B
XELOX Oxaliplatin: 130 mg/m2 iv day 1
Every 3 weeks Capecitabine: 1000 mg/m2 po twice daily days 1 to 14
Bevacizumab: 7.5 mg/kg iv day 1
mFOLFOX6 Oxaliplatin: 85 mg/m2 iv day 1
Every 2 weeks Leucovorin*: 400 mg/m2 iv day 1
Fluorouracil: 400 mg/m2 iv day 1
Fluorouracil: 2400 mg/m2 continuous iv infusion over 46 hours day 1
Bevacizumab: 5.0 mg/kg iv day 1
FOLFIRI Irinotecan: 180 mg/m2 iv day 1
Every 2 weeks Leucovorin*: 400 mg/m2 iv day 1
Fluorouracil: 400 mg/m2 iv day 1
Fluorouracil: 2400 mg/m2 continuous iv infusion over 46 hours day 1
Bevacizumab: 5.0 mg/kg iv day 1

* Investigators may elect to use low dose leucovorin i.e. either 20 mg/m2 or 50 mg total dose.

Clarke et al.

Clarke et al. BMC Cancer 2013 13:120   doi:10.1186/1471-2407-13-120

Open Data