Email updates

Keep up to date with the latest news and content from BMC Cancer and BioMed Central.

Open Access Research article

Low expression of TFPI-2 associated with poor survival outcome in patients with breast cancer

Cheng Xu1, Huijun Wang2, Hongyu He3, Fengyun Zheng4, Yating Chen4, Jin Zhang4, Xiaoyan Lin1, Duan Ma4* and Hongwei Zhang3*

Author Affiliations

1 Department of Breast Surgery, Yangpu Hospital, Tongji University, Shanghai, 200090, China

2 Children’s Hospital of Fudan University, Shanghai, 201102, China

3 Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

4 Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Institute of Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

For all author emails, please log on.

BMC Cancer 2013, 13:118  doi:10.1186/1471-2407-13-118

Published: 15 March 2013

Abstract

Background

The purpose of this study is to evaluate the prognostic value of TFPI-2 expression in breast cancer patients through examining the correlation between TFPI-2 expression and breast cancer clinicopathologic features.

Methods

Immunohistochemical staining combined with digital image analysis was used to quantify the expression of TFPI-2 protein in breast tumor tissues. For evaluation of the prognostic value of TFPI-2 expression to each clinicopathologic factor, Kaplan-Meier method and COX’s Proportional Hazard Model were employed.

Results

TFPI-2 expression was significantly correlated with tumor size, lymph node metastasis, histologic grade, clinical stage, and vessel invasion. More importantly, TFPI-2 expression was also associated with disease-free survival (DFS) of breast cancer patients. We found that patients with high TFPI-2 expression had longer DFS compared with those with low or negative expression of TFPI-2 (P <0.05, log-rank test). Cox’s regression analysis indicated that TFPI-2 expression, histologic grade, and vessel invasion might be significant prognostic factors for DFS, while TFPI-2 expression and histologic grade were the most significant independent predictors for tumor recurrence. Compared with the group with low/high TFPI-2 expression, the TFPI-2 negative group was more likely to have tumor relapse. The hazard ratio of DFS is 0.316 (P <0.01).

Conclusions

Low or negative expression of TFPI-2 is associated with breast cancer progression, recurrence and poor survival outcome after breast cancer surgery. TFPI-2 expression in breast tumors is a potential prognostic tool for breast cancer patients.

Keywords:
Breast cancer; TFPI-2; Prognosis; Immunohistochemical staining; Survival analysis