Table 2

Cytoplasmic CCNB2 staining, clinicopathological characteristics and univariate Cox Regression analysis in 80 invasive breast cancer patients
Cytoplasmic CCNB2 expression
Characteristics Negative Positive P* HR 95% CI P ¤
Age (years) 0.79 1.5 0.8-2.9 0.2
27-50 6 (24) 19 (76)
>50 13 (28) 34 (72)
Histologic type 0.04 0.8 0.4-1.5 0.5
Ductal 17 (29) 41 (71)
Lobular 0 (0) 8 (100)
Ductal + lobular 1(100) 0 (0)
Other 0 (0) 4 (100)
Tumor size (mm) 0.88 1.0 1.0-1.0 1.0
pT1 (0–20) 3 (25) 9 (75)
pT2 (>20-50) 14 (27) 38 (73)
pT3 (>50) 2 (25) 6 (75)
BRE grade 0.99 1.1 0.8-1.5 0.5
I-II 10 (28) 26 (72)
III 9 (25 ) 27 (75)
Axillary lymph node status 0.90 1.0 0.5-2.0 1.0
Negative 6 (25) 18 (75)
Positive 13 (27) 35 (73)
No. of axillary lymph nodes 0.34 1.0 0.7-1.4 0.8
1-3 4 (19) 17 (81)
≥4 9 (33) 18 (67)
ER/PR status 0.40 1.1 0.6-2.1 0.8
Negative 11 (32) 23 (68)
Positive 8 (21) 30 (79)
HER2/neu status 0.9 0.7 0.3-1.5 0.4
Positive 7 (32) 15 (68)
Negative 10 (27) 27 (73)
ASPM 0.03 0.9 0.5-20 0.9
Negative 10 (45) 12 (55)
Positive 24 (37) 41 (63)
KIAA0101 0.70 1.1 0.5-2.3 0.8
Negative 16 (48) 17 (52)
Positive 3 (8) 36 (92)
SLC27A2 0.08 0.6 0.3-1.3 0.2
Negative 11 (20) 43 (80)
Positive 8 (44) 10 (56)
CCNB2 19 (26) 53 (74) 0.004 6.1 2.0-20 0.003

P-value determined by chi-square test. * P-value of the correlation between CCNB-2 expression and clinicopatholigical parameters. ¤ P-value of hazard ratio (HR). BRE, Bloom, Richardson, Elston/Ellis; CI, confidence interval. All parameters were coded as 0 (negative) and 1 (positive) except as noted. Pathologic tumor size was coded as 1 (0-20mm), 2 (>20-50mm) and 3 (>50mm). Histologic type was coded as 1 (ductal), 2 (lobular ductal), 3 (ductal and lobular) and 4 (other). (N) = No. of patients (%).

Shubbar et al.

Shubbar et al. BMC Cancer 2013 13:1   doi:10.1186/1471-2407-13-1

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