Table 3

Univariate analysis of overall (OS) and event-free survival (EFS) in T-ALL patients

Variables

OSa (95% CI)

pb

HRc (Lower-Upper)

EFSa (95% CI)

pb

HRc (Lower-Upper)


Age (Years)

< 10

45.1 (48.9-74.5)

0.275

0.77 (0.48-1.24)

28.8 (30.8-57.8)

0.044

0.58 (0.34-1.00)

10-18

56.7 (60.7-88.0)

51.2 (51.9-85.8)

WBC (x109/L)

<50

47.6 (51.6-79.4)

0.606

0.88 (0.55-1.42)

41.3 (40.9-73.3)

0.859

1.05 (0.63-1.76)

≥50

53.3 (57.1-82.5)

36.7 (39.2-68.5)

EGIL

T-I

33.3 (28.8-77.2)

0.411

0.93 (0.74-1.18)

31.3 (26.9-75.9)

0.954

0.98 (0.77-1.24)

T-II

51.7 (48.2-88.7)

36.4 (31.5-75.5)

T-III

61.8 (56.1-90.7)

45.0 (32.9-78.6)

T-IV

51.0 (44.0-70.9)

36.7 (30.2-60.9)

CD10

Positive

52.8 (50.6-86.9)

0.696

1.12 (0.63-1.97)

48.1 (42.6-83.6)

0.097

1.67 (0.89-3.08)

Negative

50.0 (54.1-79.4)

28.8 (31.6-59.5)

Skin colour

White

55.0 (54.5-81.5)

0.451

1.20 (0.74-1.96)

33.3 (32.1-61.5)

0.331

0.78 (0.46-1.30)

Non-white

47.4 (52.8-77.8)

43.4 (45.9-75.9)

NOTCH1

Mutated

53.3 (54.6-80.8)

0.479

1.19 (0.73-1.93)

34.2 (30.5-60.9)

0.382

0.79 (0.47-1.34)

WT

48.7 (52.7-78.2)

42.1 (45.5-74.2)

Type of mutation

Point

42.4 (32.4-61.9)

0.031

0.43 (0.19-0.95)

30.4 (19.1-51.4)

0.289

0.65 (0.28-1.47)

Complex

66.7 (65.6-100.9)

40.0 (31.4-79.4)

FBXW7

Mutated

61.9 (54.8-102.3)

0.512

1.28 (0.60-2.73)

58.3 (38.9-104.9)

0.586

1.29 (0.51-3.31)

WT

51.7 (59.2-82.3)

41.4 (47.2-74.7)

NOTCH1-FBXW7

Mutated

58.1 (62.5-89.6)

0.319

1.32 (0.76-2.28)

40.5 (37.6-72.3)

0.286

0.71 (0.37-1.34)

WT

47.9 (50.7-82.3)

48.5 (51.1-87.7)

SIL-TAL1

Positive

37.8 (32.1-68.3)

0.012

0.53 (0.32-0.88)

18.2 (11.9-48.7)

0.004

0.46 (0.26-0.81)

Negative

56.5 (60.9-81.9)

43.8 (46.4-71.1)

HOX11L2

Expressed

40.0 (13.4-44.6)

0.469

0.74 (0.32-1.71)

50.0 (14.3-50.2)

0.806

1.14 (0.41-3.16)

Absent

48.6 (54.1-75.2)

35.6 (39.3-63.6)

KRAS

Mutated

60.0 (32.7-78.1)

0.585

1.32 (0.48-3.67)

57.1 (21.4-79.7)

0.584

1.38 (0.43-4.46)

WT

49.5 (55.7-77.9)

36.9 (41.5-66.9)

PTEN

Mutated

44.4 (15.1-56.1)

0.359

0.65 (0.26-1.66)

30.8 (34.6-66.1)

0.693

0.31 (0.53-1.51)

WT

57.5 (63.5-86.6)

42.0 (41.0-71.8)

Induction Responsed

Yes

68.4 (76.2-106.9)

<0.001

3.45 (1.74-6.85)

70.3 (75.5-107.7)

<0.001

3.54 (1.71-7.32)

No

33.3 (25.9-55.9)

32.4 (23.4-48.6)


a Survival in percent; b Mantel-Cox (log-rank) test; c last category used as reference; d evaluated in day 30-33 of treatment; HR hazard risk, WT wild-type, WBC white blood cells count

Mansur et al. BMC Cancer 2012 12:9   doi:10.1186/1471-2407-12-9

Open Data