Kaplan-Meier overall survival curves for T-ALL patients. (A) Overall survival (OS) of T-ALL patients. In this analysis were included all 138 patients with T-ALL. (B) NOTCH1 type of mutation (point mutations vs. complex mutations) OS curve. For the construction of this curve were included all 60 patients with NOTCH1 mutations, being 33 patients harbouring point mutations and 27 complex mutations. (C) OS curve for NOTCH1-FBXW7 status. In this Kaplan-Meier OS curve were analyzed 110 T-ALL patients with NOTCH1-FBXW7 status determined, 62 with NOTCH1-FBXW7 mutations and 48 displaying WT profile. (D) OS according to the presence or absence of SIL-TAL1 fusion gene. Symbols represent censored cases. The SIL-TAL1 fusion OS analysis included 129 T-ALL cases, being 37 SIL-TAL1+ and 92 SIL-TAL1-.
Mansur et al. BMC Cancer 2012 12:9 doi:10.1186/1471-2407-12-9