Open Access Highly Accessed Research article

Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells

Benjamin Blaser, Laurent Waselle, Anne Dormond-Meuwly, Marc Dufour, Didier Roulin, Nicolas Demartines and Olivier Dormond*

Author Affiliations

Department of Visceral Surgery, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Pavillon 4, Av. de Beaumont, 1011 Lausanne, Switzerland

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BMC Cancer 2012, 12:86  doi:10.1186/1471-2407-12-86

Published: 8 March 2012

Additional files

Additional file 1:

Effects of rapamycin, PP242 and NVP-BEZ235 on the growth of Caco-2, SW620, HT29 and HCT-116 colon cancer cells. Caco-2, SW620, HT29 and HCT-116 colon cancer cells were treated with 10 nM of rapamycin, 100 nM of PP242, 100 nM of NVP-BEZ235 or DMSO as a control for 48 hours. Cell growth was determined using a colorimetric MTS assay. Columns, mean cell growth relative to control of three independent experiments; bars, SD. P < 0.05, compared to control or otherwise as specified by brackets.

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Additional file 2:

Effects of rapamycin, PP242 and NVP-BEZ235 on the growth of Caco-2, SW620, HT29 and HCT-116 colon cancer cells. Caco-2, SW620, HT29 and HCT-116 colon cancer cells were treated with 10 nM of rapamycin, 100 nM of PP242, 100 nM of NVP-BEZ235 or DMSO as a control for 48 hours. Cell growth was determined using a colorimetric MTS assay. Columns, mean cell growth relative to control of three independent experiments; bars, SD. P < 0.05, compared to control or otherwise as specified by brackets.

Format: PPT Size: 183KB Download file

This file can be viewed with: Microsoft PowerPoint Viewer

Open Data