Table 3

Relationship between intensity of BRMS1 expression, ulceration, tumor thickness and markers of proliferation

Intensity of cytoplasmic

BRMS1 staining


Clinical parameter

Expression

Weak

Stronga

P


Mean tumor depth (mm)

3.26 (3.11)b

1.92 (1.89)

0.024


Ulceration

No

71

23

Yes

44

2

0.004


Marker


Low

53

19

Cyclin A

High

65

6

0.007


Low

70

20

Ki67

High

48

5

0.068


Cyclin D3

Low

76

23

High

42

2

0.008


Low

32

17

p21

High

31

3

0.009


aLow protein expression was defined as immunoreactivity in less than 5% of the tumor cells

(cyclin A, Ki67, cyclin D3, p21)[21,22,24]

bSD

Slipicevic et al. BMC Cancer 2012 12:73   doi:10.1186/1471-2407-12-73

Open Data