Table 2

Relationship between cytoplasmic BRMS1 score index, ulceration, tumor thickness, cyclin D3 and activation of ERK1/2 and Akt

Cytoplasmic BRMS1 score index


Clinical parameter

Expression

Low

Higha

P


Mean tumor depth (mm)

3.60 (3.29)b

2.42 (2.46)

0.040


No

41

53

Ulceration

Yes

30

16

0.020


Marker


Cyclin D3

Low

42

57

High

32

12

0.001


Low

43

29

Cytoplasmic p-ERK

High

32

46

0.033


Low

46

59

0.013

Nuclear p-Akt

High

26

12


aHigh score index defined as ≥ 4

Low protein expression was defined as immunoreactivity in less than 5% (cyclin D3) [21]

in < 50% of the tumor cells (p-Akt) [25], or total lack of expression (p-ERK) [23]

bSD

Slipicevic et al. BMC Cancer 2012 12:73   doi:10.1186/1471-2407-12-73

Open Data