Table 2

GPER IHC scoring in tissue microarrays
Tissue Score 0-1+ Score 2-3+ P-values (compared with cancer adjacent tissues) P-values (compared with normal lung tissues)
Adenocarcinoma 2 of 15 (13.3%) 13 of 15 (86.7%) P<0.0001 P=0.0007
Squamous cell carcinoma 13 of 33 (40%) 20 of 33 (60.0%) P<0.0001 P= 0.0024
Large cell carcinoma 2 of 8 (25%) 6 of 8 (75%) P<0.0001 P=0.0011
Metastatic adenocarcinoma 1 of 6 (16.7%)) 5 of 6 (83.3%) P=0.0002 P=0.0013
Cancer adjacent lung tissue 41 of 42 (97.6%) 1 of 42 (2.4%) No significant
Normal lung tissue 8 of 8 (100%) 0 of 8 (0) No significant

The scoring pattern for GPR30 staining as follows. Score 0, negative staining for all cells; score 1+, weakly positive for cytosolic staining in <10% of cells; score 2+, moderate to strong positive staining covering between 10 to 50% of cells and score 3+, strongly positive staining including >50% cells.

Jala et al.

Jala et al. BMC Cancer 2012 12:624   doi:10.1186/1471-2407-12-624

Open Data