Table 2 |
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| GPER IHC scoring in tissue microarrays | ||||
| Tissue | Score 0-1+ | Score 2-3+ | P-values (compared with cancer adjacent tissues) | P-values (compared with normal lung tissues) |
| Adenocarcinoma | 2 of 15 (13.3%) | 13 of 15 (86.7%) | P<0.0001 | P=0.0007 |
| Squamous cell carcinoma | 13 of 33 (40%) | 20 of 33 (60.0%) | P<0.0001 | P= 0.0024 |
| Large cell carcinoma | 2 of 8 (25%) | 6 of 8 (75%) | P<0.0001 | P=0.0011 |
| Metastatic adenocarcinoma | 1 of 6 (16.7%)) | 5 of 6 (83.3%) | P=0.0002 | P=0.0013 |
| Cancer adjacent lung tissue | 41 of 42 (97.6%) | 1 of 42 (2.4%) | No significant | |
| Normal lung tissue | 8 of 8 (100%) | 0 of 8 (0) | No significant | |
The scoring pattern for GPR30 staining as follows. Score 0, negative staining for all cells; score 1+, weakly positive for cytosolic staining in <10% of cells; score 2+, moderate to strong positive staining covering between 10 to 50% of cells and score 3+, strongly positive staining including >50% cells.
Jala et al. BMC Cancer 2012 12:624 doi:10.1186/1471-2407-12-624
