Table 1

TOX3 and LOC643714 mRNA expression compared with clinical and pathological characteristics
n TOX3 mRNA p-value n LOC643714 mRNA p-value
139 median (25% and 75%) 126 median (25% and 75%)
Age
< 50 59 (42%) 1.92 (0.9 - 4.5) 0.89 53 (42%) 3.1 E-4 (5.6 E-6 - 1.5 E-2) 0.07
≥ 50 80 (58%) 1.68 (1.1 - 4.0) 73 (58%) 1.7 E-3 (1.1 E-4 - 8.5 E-2)
Tumour size (mm)
≤ 20 42 (31%) 1.5 (1.0 - 4.8) 0.45 39 (31%) 6.4 E-4 (2.7 E-5 - 1.0 E-2) 0.26
> 20 95 (69%) 2.0 (1.0 - 4.5) 85 (69%) 1.1 E-3 (9.2 E-5 - 8.5 E-2)
unknown 2 2
Estrogen receptor
negative 44 (33%) 1.3 (0.4 - 3.3) 0.004 41 (34%) 9.3 E-6 (6.4 E-7 - 5.5 E-4) < 0.001
positive 91 (67%) 2.1 (1.1 - 4.5) 81 (66%) 2.4 E-3 (4.6 E-4 - 9.8 E-2)
unknown 4 4
Progesterone receptor
negative 65 (49%) 1.4 (0.6 - 4.2) 0.005 59 (50%) 1.9 E-4 (1.4 E-6 - 3.1 E-3) < 0.001
positive 67 (51%) 2.1 (1.3 - 4.3) 60 (50%) 3.3 E-3 (4.2 E-4 - 0.5)
unknown 7 7
ErbB2 status
negative 114 (83%) 1.8 (1.0 - 4.2) 0.81 107 (86%) 1.1 E-3 (6.6 E-5 - 7.7 E-2) 0.04
positive 24 (17%) 1.9 (0.8 - 5.0) 18 (14%) 2.7 E-4 (4.7 E-5 - 9.2 E-4)
unknown 1 1
Nodal status
negative 56 (44%) 1.3 (0.4 - 3.4) < 0.001 53 (46%) 5.3 E-4 (1.9 E-6 - 2.3E-2) 0.04
positive 71 (56%) 2.2 (1.2 - 5.3) 62 (54%) 1.4 E-3 (2.0 E-4 - 5.7 E-2)
unknown 12 11
Ki67
Low 97 (71%) 2.1 (1.1 - 4.4) 0.026 87 (70%) 2.4 E-3 (2.2 E-4 - 9.0 E-2) < 0.001
High 39 (29%) 1.2 (0.7 - 2.4) 37 (30%) 9.6 E-5 (1.9 E-6 - 9.0 E-4)
unknown 3 2
Histograde
1 12 (9%) 1.6 (0.8 - 3.5) 0.16 12 (9%) 1.1 E-3 (2.7 E-4 - 3.5 E-2) 0.01
2 78 (57%) 1.9 (1.1 - 4.4) 69 (56%) 3.5 E-3 (1.9 E-4 - 9.8 E-2)
3 47 (34%) 1.6 (0.5 - 4.2) 43 (35%) 2.3 E-4 (3.3 E-6 - 1.5 E-3)
unknown 2 2
Familial status 1
BRCA2 26 (19%) 2.9 (0.8 - 5.1) 0.90 25 (20%) 6.7 E-4 (1.2 E-4 - 4.2 E-3) 0.40
Non-BRCA2 112 (81%) 1.6 (1.0 - 4.2) 100 (80%) 1.2 E-3 (6.3 E-5 - 6.4 E-2)
unknown 1 1
Subtype
Basal 20 (17%) 0.5 (0.1 – 1.3) < 0.001 23 (21%) 3.1 E-6 (2.3 E-7 - 2.0 E-4) < 0.001
ERBB2 15 (12%) 1.6 (1.2 - 5.0) 9 (8%) 9.7 E-4 (2.7 E-4 - 1.5 E-2)
Luminal A 43 (36%) 1.6 (1.1 - 3.1) 38 (35%) 8.9 E-3 (5.0 E-4 - 9.8 E-2)
Luminal B 30 (25%) 4.0 (1.6 - 5.4) 28 (26%) 1.2 E-3 (6.7 E-4 – 3.0 E-1)
Normal-like 12 (10%) 1.8 (1.2 - 4.4) 10 (9%) 5.8 E-4 (3.4 E-5 - 2.7 E-3)
Unclass/unknown 19 18
Histological type
Ductal 116 (86%) 2.1 (1.0 - 4.5) 0.12 105 (86%) 1.1 E-3 (9.2 E-5 - 5.2 E-2) 0.91
Lobular 11 (8%) 1.3 (1.3 - 2.2) 9 (7%) 6.2 E-4 (1.2 E-4 - 7.8 E-3)
other 8 (6%) 1.0 (0.6 - 1.5) 8 (7%) 9.8 E-5 (5.2 E-6 - 2.2 E-2)
unknown 4 4
Metastasis
negative 63 (50%) 1.6 (0.9 - 3.1) 0.18 63 (55%) 6.4 E-4 (6.3 E-6 - 1.9 E-2) 0.16
positive 63 (50%) 1.9 (1.1 - 4.9) 52 (45%) 1.6 E-3 (1.4 E-4 - 8.1 E-2)
unknown 13 11

The table shows the median and the 25th and 75th percentiles. The p-value is calculated with log2 transformed data using a t-test or ANOVA.

1 One tumour sample was BRCA1 positive and was not used in familial status calculations.

Gudmundsdottir et al.

Gudmundsdottir et al. BMC Cancer 2012 12:621   doi:10.1186/1471-2407-12-621

Open Data