|Joint effects of unfavorable genotypes in case patients and control subjects in Chinese|
|Risk group (no. unfavorable genotypes)||Cases||Controls||OR (95% CI)*|
|Reference groupa (n = 0)||147||205||Reference|
|Low-risk reference group (n = 1)||96||83||1.51 (1.05- 2.17)|
|Medium-risk group (n = 2)||108||76||1.86 (1.30-2.67)|
|High-risk group b (n ≥3)||11||3||4.86 (1.33-17.71)|
|P for trend||<0.001|
*Adjusted for age, gender, smoking status, and pack-years.
aReference group: GPX1 promoter: CC, MnSOD V16A: TT, SOD3 T58A: GG, and NOS1 3' UTR: CT+TT.
bBecause the subject number in group ‘4’ was sparse (one control and three patients), the subjects with greater than three unfavourable genotypes were combined as the high-risk group.
Zhao et al. BMC Cancer 2012 12:617 doi:10.1186/1471-2407-12-617