Table 3

Allelic and genotypic frequencies and risks for glioma in Chinese
Genotyped SNPs MAF Common homozygote (n) Heterozygote (n) Rare homozygote (n) Heterozygote and rare Homozygote (n) P for trend
GPX1 promoter (rs1800668) Case 0.12 301 66 13 79
Control 0.09 314 64 4 68 0.110
OR (95% CI)* Reference 1.05 (0.72-1.53) 3.30 (1.07-10.24) 1.18 (0.82-1.69)
CAT 5’region (rs769214) Case 0.28 198 146 32 178
Control 0.29 192 146 36 182 0.609
OR (95% CI)* Reference 0.93 (0.69- 1.26) 0.83 (0.49- 1.39) 0.91 (0.68- 1.21)
CAT 5’region (rs7943316) Case 0.33 180 140 53 193
Control 0.29 195 153 32 185 0.074
OR (95% CI)* Reference 1.04 (0.77- 1.41) 1.16 (0.75- 1.79) 1.19 (0.89- 1.58)
PON1 3' UTR (rs854552) Case 0.22 237 120 23 143
Control 0.23 231 126 24 150 0.653
OR (95% CI)* Reference 0.96 (0.70- 1.30) 0.96 (0.53- 1.75) 0.96 (0.71- 1.28)
PON1 Q192R (rs662) Case 0.35 161 158 52 210
Control 0.36 159 167 52 219 0.833
OR (95% CI)* Reference 0.98 (0.72- 1.34) 1.06 (0.68- 1.65) 1.00 (0.75- 1.33)
NQO1 3' UTR (rs10517) Case 0.39 142 170 60 230
Control 0.35 154 181 44 225 0.162
OR (95% CI)* Reference 0.99 (0.73- 1.35) 1.44 (0.92- 2.26) 1.08 (0.81- 1.45)
NQO1 S1P (rs1800566) Case 0.46 109 181 78 259
Control 0.47 108 187 86 273 0.610
OR (95% CI)* Reference 1.00 (0.71- 1.39) 0.93 (0.62- 1.40) 0.98 (0.71- 1.34)
MnSOD V16A (rs4880) Case 0.22 241 107 31 138
Control 0.12 293 81 6 87 <0.001
OR (95% CI)* Reference 1.55 (1.11- 2.16) 6.05 (2.48- 14.74) 1.86 (1.35- 2.55)
MnSOD 3' UTR (rs5746136) Case 0.51 95 182 100 282
Control 0.46 118 178 85 263 0.058
OR (95% CI)* Reference 1.17 (0.83- 1.64) 1.34 (0.90- 1.99) 1.22 (0.89- 1.68)
SOD3 T58A (rs2536512) Case 0.25 235 96 44 140
Control 0.11 283 73 25 98 <0.001
OR (95% CI)* Reference 1.51 (1.06- 2.14) 2.01 (1.20- 3.39) 1.64 (1.20- 2.23)
SOD3 3' UTR (rs2695232) Case 0.41 142 165 75 240
Control 0.41 134 172 70 242 0.922
OR (95% CI)* Reference 0.87 (0.63- 1.19) 0.97 (0.65- 1.45) 0.90 (0.67- 1.20)
NOS1 3' UTR (rs2682826) Case 0.25 209 104 23 127
Control 0.28 193 164 24 188 0.017
OR (95% CI)* Reference 0.57 (0.42- 0.79) 0.87 (0.47- 1.59) 0.61 (0.45- 0.82)
NOS1 Q902H (rs1047735) Case 0.46 123 165 90 255
Control 0.49 101 183 94 277 0.197
OR (95% CI)* Reference 0.80 (0.57- 1.11) 0.85 (0.57- 1.25) 0.81 (0.60- 1.11)
NOS2 L608S (rs2297518) Case 0.19 241 120 8 128
Control 0.17 255 113 9 122 0.584
OR (95% CI)* Reference 1.10 (0.80- 1.50) 0.92 (0.35- 2.42) 1.08 (0.80- 1.47)
NOS2 promoter (rs10459953) Case 0.40 140 178 64 242
Control 0.44 122 184 73 257 0.173
OR (95% CI)* Reference 0.88 (0.64- 1.21) 0.80 (0.53- 1.21) 0.86 (0.64- 1.16)
NOS3 D298E (rs1799983) Case 0.15 282 77 17 94
Control 0.12 278 84 15 99 0.856
OR (95% CI)* Reference 0.91 (0.64- 1.29) 1.12 (0.55- 2.29) 0.94 (0.68- 1.30)

*Multivariable adjustment by age, gender (male or female), smoking status (never, former or current), and pack-years.

Data in boldface represent P < 0.05.

MAF: Minor Allele frequency.

Zhao et al.

Zhao et al. BMC Cancer 2012 12:617   doi:10.1186/1471-2407-12-617

Open Data