Table 3

Multivariate analyses of disease-specific, metastasis-free, and urinary bladder recurrence-free survival
Variable Category Disease-specific survival Metastasis-free survival UB Recurrence-free survival
Relative risk 95% Confidence interval pvalue Relative risk 95% Confidence interval pvalue Relative risk 95% Confidence interval pvalue
Nodal metastasis Positive vs. negative 5.602 2.912 ~ 10.776 <0.001* 3.174 1.648 ~ 6.115 0.001* - - -
Perineurial invasion Present vs. absent 3.291 1.522 ~ 7.117 0.002* 2.460 1.120 ~ 5.401 0.025* - - -
Multifocality Multifocal vs. single 2.816 1.321 ~ 6.004 0.007* 2.408 1.124 ~ 5.158 0.024* - - -
Pattern of invasion Infiltrative vs. trabecular vs. non-invasive/Nodular 1.596 1.090 ~ 2.337 0.016* 1.307 0.906 ~ 1.885 0.152 - - -
Histological grade High grade vs. low grade 3.751 1.170 ~ 12.024 0.026* 4.187 1.221 ~ 14.364 0.023* 2.113 1.173-3.805 0.013*
HuR Cyto. Exp. High vs. low 1.996 1.039 ~ 3.834 0.038* 1.880 1.074 ~ 3.291 0.027* 1.398 0.886-2.204 0.150
Vascular invasion Present vs. absent 1.549 0.823 ~ 2.913 0.175 2.872 1.486 ~ 5.550 0.002* - - -
Cyclin A expression High vs. low 1.632 0.909 ~ 2.932 0.101 1.703 0.994 ~ 2.918 0.053 - - -
Primary tumor (T) T2 ~ T4 vs. Ta ~ T1 1.412 0.586 ~ 3.400 0.442 0.916 0.419 ~ 2.003 0.826 - - -
Tumor location Both renal pelvis and ureter vs. one location alone 0.950 0.614 ~ 1.471 0.819 0.786 0.572 ~ 1.340 0.541 - - -
Mitotic rate ≥10 vs. <10/10 hpf - - - 0.849 0.514 ~ 1.402 0.523 - - -
Gender Male vs. female - - - - - - 1.607 1.030-2.507 0.036*

† Cyto. Exp., cytoplasmic expression. * Statistically significant.

Liang et al.

Liang et al. BMC Cancer 2012 12:611   doi:10.1186/1471-2407-12-611

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