Open Access Research article

Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers

Giorgio Secreto1*, Elisabetta Venturelli1, Elisabetta Meneghini2, Maria Luisa Carcangiu3, Biagio Paolini3, Roberto Agresti4, Cristina Pellitteri4, Franco Berrino1, Massimo Gion5, Patrizia Cogliati1, Giuseppina Saragò1 and Andrea Micheli6

Author Affiliations

1 Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

2 Descriptive Studies and Health Planning Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

3 Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

4 Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

5 Association for Application of Biotechnologies in Oncology and Center for the Study of Biological Markers of Malignancy, Regional Hospital, Local Health Unit (AULSS) No 12, Venice, Italy

6 Scientific Consultant for Scientific Direction and Descriptive Studies and Health Planning Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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BMC Cancer 2012, 12:599  doi:10.1186/1471-2407-12-599

Published: 14 December 2012

Additional files

Additional file 1:

A word file containing tables and relating comments of supplementary analyses on all (natural and surgical) and on surgical postmenopausal women. Additional Table S1: Androgen receptor (AR) expression and characteristics of all postmenopausal breast cancer women. Additional Table S2: Serum testosterone (mean ± SD) by androgen and estrogen receptor expression in breast cancer women who had had a surgical menopause. Additional Table S3: Odds ratios of AR expression by testosterone tertiles in all postmenopausal women with ER-positive breast cancer. Additional Table S4: Odds ratios of AR expression by testosterone tertiles in postmenopausal women with ER-negative breast cancer (all postmenopausal and naturally menopausal women).

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