Table 4

Synergy and multiplicative indices between asbestos exposure and cigarette smoking
Cigarette smoking (pack-years) Asbestos exposure Label Cases Controls Odds ratio* 95% CI
< 10 None R0 84 745 1.0 -
Low 13 69 1.47 (0.77 – 2.81)
Medium/High RA 2 7 2.20 0.42 – 11.41)
10 - < 40 None 630 778 5.28 (3.90 – 7.14)
Low 90 90 6.67 (4.41 – 10.10)
Medium/High 20 13 10.39 (4.83 – 22.36)
≥ 40 None RS 678 266 17.68 (12.90 – 24.22)
Low --- 85 40 15.62 (9.72 – 25.09)
Medium/High RAS 16 3 38.59 (10.78 – 138.08)
Synergy Index 2.10
Multiplicativity Index 0.99

* adjusted for age, province, occupational exposure to diesel and silica, and second hand cigarette smoke.

Villeneuve et al.

Villeneuve et al. BMC Cancer 2012 12:595   doi:10.1186/1471-2407-12-595

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