Email updates

Keep up to date with the latest news and content from BMC Cancer and BioMed Central.

Open Access Highly Accessed Research article

Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces

Paul J Villeneuve123*, Marie-Élise Parent4, Shelley A Harris2356, Kenneth C Johnson7 and The Canadian Cancer Registries Epidemiology Research Group

Author affiliations

1 Population Studies Division, Health Canada, Ottawa, Ontario, Canada

2 Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

3 Occupational Cancer Research Centre, Toronto, Ontario, Canada

4 INRS-Institut Armand-Frappier, University of Quebec, Laval, Quebec, Canada

5 Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

6 Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada

7 Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Canada

For all author emails, please log on.

Citation and License

BMC Cancer 2012, 12:595  doi:10.1186/1471-2407-12-595

Published: 13 December 2012

Abstract

Background

Asbestos is classified as a human carcinogen, and studies have consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few studies have evaluated risks in population-based settings where there is a greater variety in the types of occupations, and exposures.

Methods

This was a population based case–control study with 1,681 incident cases of lung cancer, and 2,053 controls recruited from 8 Canadian provinces between 1994 and 1997. Self-reported questionnaires were used to elicit a lifetime occupational history, including general tasks, and information for other risk factors. Occupational hygienists, who were blinded to case–control status, assigned asbestos exposures to each job on the basis of (i) concentration (low, medium, high), (ii) frequency (<5%, 5-30%, and >30% of the time in a normal work week), and (iii) reliability (possible, probable, definite). Logistic regression was used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CI).

Results

Those occupationally exposed to (i) low, and (ii) medium or high concentrations of asbestos had ORs for lung cancer of 1.17 (95% CI=0.92 – 1.50) and 2.16 (95% CI=1.21-3.88), respectively, relative to those who were unexposed. Medium or high exposure to asbestos roughly doubled the risk for lung cancer across all three smoking pack-year categories. The joint relationship between smoking and asbestos was consistent with a multiplicative risk model.

Conclusions

Our findings provide further evidence that exposure to asbestos has contributed to an increased risk of lung cancer in Canadian workplaces, and suggests that nearly 3% of lung cancers among Canadian men are caused by occupational exposure to asbestos.

Keywords:
Lung cancer; Asbestos; Cigarette smoking; Case–control; Occupational epidemiology