Open Access Research article

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers

Sylvia Hartmann1*, Claudio Agostinelli2, Jürgen Diener3, Claudia Döring1, Stefano Fanti4, Pier Luigi Zinzani5, Andrea Gallamini6, Lothar Bergmann7, Stefano Pileri2 and Martin-Leo Hansmann1

Author Affiliations

1 Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany

2 Department of Haematology and Oncological Sciences “L. and A. Seràgnoli”, Haematopathology Section, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

3 Department of Nuclear Medicine, Goethe University, Frankfurt am Main, Germany

4 Department of Nuclear Medicine, Policlinico Sant’Orsola-Malpighi, Bologna University, Via Massarenti 9, Bologna 40138, Italy

5 Institute of Hematology and Medical Oncology L. e A. Seràgnoli, Policlinico Sant'Orsola-Malpighi, University of Bologna, Bologna, Italy

6 Hematology Department and BMT Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy

7 Department of Haematology, Goethe University, Frankfurt am Main, Germany

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BMC Cancer 2012, 12:586  doi:10.1186/1471-2407-12-586

Published: 10 December 2012

Additional files

Additional file 1:

Table S1. Antibodies, dilutions, suppliers and detection systems used in the present study.

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Additional file 2:

Figure S1. Kaplan-meier Analysis of GLUT1 and LDHA expression as well as Interim PET. a. Kaplan-Meier Analysis of different GLUT1 expression patterns (overall survival). b. Kaplan-Meier Analysis of different GLUT1 expression patterns (progression free survival). c. Kaplan-Meier Analysis of LDHA expression (overall survival). d. Kaplan-Meier Analysis of LDHA expression (progression free survival). e. Kaplan-Meier-Analysis of Interim-PET-positive and -negative cases (overall survival). f. Kaplan-Meier-Analysis of Interim-PET-positive and -negative cases (progression free survival).

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Additional file 3:

Figure S2. SUVmax in different GLUT1 expression patterns. a. Prechemotheraphy SUVmax values in 8 patients of the first series stained on full sections. b. Prechemotheraphy SUVmax values in 13 patients of the second series stained on TMA format.

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