FITC-Dextran accumulation in tumour tissue normalized to liver tissue control. High molecular weight dextran (2 MDa, ~80 nm) was injected IV into tumour animals as a model nanocarrier and allowed to distribute prior to sacrifice. 3 week old MFP tumours showed higher accumulation of the nanocarrier than 5 week old SC tumours at a 90% confidence interval. All data are shown as the mean of n = 4 animals ± SD. Lines connecting bars denote statistical significance, P < 0.10.
Ho et al. BMC Cancer 2012 12:579 doi:10.1186/1471-2407-12-579