Table 2

Associations between LINE-1 methylation in primary CRC and clinicopathological features
n LINE-1 methylation p-value
Age >70 22 69.5 (62.1 – 70.7) 0.17
≤70 21 59.5 (48.4 – 73.4)
Gender male 25 64.4 (48.9 – 70.4) 0.49
female 18 68.3 (52.3 – 74.3)
Site proximal 19 65.3 (53.2 – 69.8) 0.77
distal 24 69.3 (49.0 – 73.8)
Histology well 16 68.6 (49.0 – 72.1) 0.98
moderately 27 65.7 (54.8 – 71.9)
T factor 1 1 76.3 0.55
2 7 67.3 (49.3 – 70.7)
3 26 67.3 (49.3 – 70.7)
4 9 58.2 (48.2 – 69.3)
N factor 0 20 69.5 (49.7 – 75.0) 0.67
1 16 59.4 (48.9 – 74.1)
2 7 65.7 (62.9 – 68.0)
M factor 0 34 67.3 (50.3 – 73.8) 0.49
1 9 60.7 (48.2 – 70.0)
Stage I 4 72.3 (69.5 – 75.0) 0.47
II 15 69.3 (49.4 – 73.8)
III 15 64.4 (50.5 – 68.1)
IV 9 60.7 (48.2 – 70.0)

n, number of patients.

LINE-1 methylation levels are shown as the median (25th percentile – 75th percentile).

Histology of adenocarcinoma was sub-classified into well- and moderately-differentiated adenocarcinoma according to their grading.

TNM factors and stage were defined according to the International Union Against Cancer (UICC) TNM system.

Matsunoki et al.

Matsunoki et al. BMC Cancer 2012 12:574   doi:10.1186/1471-2407-12-574

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