Comparison of adverse events between the gefitinib and erlotinib groups. The graphs show the proportion of adverse events in all grade (A), and in grade ≥ 2 (B). In all grade, the patients treated with gefitinib had a significantly higher frequency of liver dysfunction than did patients treated with erlotinib (*p = 0.003). In grade ≥ 2, liver dysfunction occurred significantly more often in the gefitinib group than in the erlotinib group (*p = 0.04).
Suzumura et al. BMC Cancer 2012 12:568 doi:10.1186/1471-2407-12-568