Table 2 |
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| The association of WHO grade to C4d positive tumor area, C4d positive endothelium, and to the fraction of C4d positive endothelium | ||||
| C4d EXT | Mean(%) | Std.(%) | Median(%) | p-value |
| Grade I | 18.4 | 22.5 | 8.2 | 0.041* |
| Grade II | 2.1 | 8.7 | 0.0 | |
| Grade III | 0.7 | 0.9 | 0.4 | |
| Grade IV | 8.2 | 17.3 | 0.8 | 0.016** |
| C4d END | ||||
| Grade I | 0.1 | 0.1 | 0.0 | n.s.* |
| Grade II | 0.1 | 0.2 | 0.0 | |
| Grade III | 0.3 | 0.5 | 0.0 | |
| Grade IV | 0.3 | 0.6 | 0.0 | n.s.** |
| C4d/CD34 | ||||
| Grade I | 4.8 | 12.3 | 0.0 | n.s.* |
| Grade II | 3.0 | 7.5 | 0.0 | |
| Grade III | 12.1 | 19.1 | 0.0 | |
| Grade IV | 20.3 | 71.3 | 0.0 | n.s.** |
C4d EXT = C4d positive tumor area fraction, C4d END = C4d positive endothelial area fraction, C4d / CD34 = the proportion of C4d positive endothelial area fraction of the CD34 positive endothelium. p-value; * = Mann–Whitney U-test between pilocytic (grade I) and diffusely infiltrating (grades II-IV) astrocytomas; ** = Kruskal-Wallis test between different grades of diffusely infiltrating (grade II-IV) astrocytomas.
Mäkelä et al. BMC Cancer 2012 12:565 doi:10.1186/1471-2407-12-565
