Table 2

CYP1A2 rs762551 polymorphism and cancer risk stratified by characteristics of studies
Variables Genotype of rs762551 (Cases/Controls) CC vs AA Dominant model (CC+CA vs AA) Recessive model (CC vs CA+AA)
Total AA AC CC OR (95% CI) OR (95% CI) OR (95% CI)
All 8218/11165 3750/5374 3567/4720 901/1071 1.30(1.02-1.64)* 1.19(1.04-1.36)* 1.19(0.99-1.44)
Cancer site
 Lung 814/1018 277/426 380/443 157/149 1.27(0.63-2.61) 1.09(0.63-1.89) 1.27(0.82-1.95)
 Colorectal 734/747 288/366 362/310 84/71 1.50(0.96-2.33) 1.52(0.95-2.42) 1.15(0.73-1.81)
 Breast 5274/7874 2544/3848 2204/3331 526/695 1.44(0.82-2.55) 1.07(0.93-1.24) 1.15(0.73-1.81)
 Other 1396/1526 641/734 621/636 134/156 1.04(0.79-1328) 1.12(0.96-1.31) 0.97(0.73-1.30)
Ethnicity
 Caucasian 5751/8345 2804/4199 2417/3463 530/683 1.29(1.27-1.63)* 1.17(1.02-1.34)* 1.19(0.98-1.45)
 Asian 2253/2423 867/989 1055/1086 331/348 1.27(0.83-1.93) 1.24(0.93-1.66) 1.10(0.76-1.59)
 Mixed 214/397 79/186 95/171 40/40 1.34(0.14-12.95) 0.87(0.17-4.40) 1.68(0.44-6.35)
Source of Controls
 Population 5549/7936 2590/3777 2388/3387 571/772 1.01(0.89-1.14) 1.02(0.92-1.14) 1.00(0.89-1.13)
 Hospital 2556/2930 1114/1426 1128/1219 314/285 1.35(0.97-1.88) 1.21(0.98-1.50) 1.26(0.96-1.65)
 Other 113/299 46/171 51/114 16/14 4.25(1.93-9.34)* 1.95(1.25-3.02)* 3.36(1.58-7.13)*

* P<0.05.

Wang et al.

Wang et al. BMC Cancer 2012 12:528   doi:10.1186/1471-2407-12-528

Open Data