The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors
1 Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada
2 Faculty of Health Disciplines, Athabasca University, Athabasca, Canada
3 Faculty of Kinesiology, University of Calgary, Calgary, Canada
4 Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
5 Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
6 School of Public Health, University of Alberta, Edmonton, Canada
7 Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, Maryland
8 Faculty of Medicine, University of Calgary, Calgary, Canada
9 Department of Epidemiology, Alberta Health Services, Calgary, Canada
10 Faculty of Physical Education and Recreation, University of Alberta, E-488 Van Vliet Center, Edmonton, AB, Canada
BMC Cancer 2012, 12:525 doi:10.1186/1471-2407-12-525Published: 16 November 2012
Limited research has examined the association between physical activity, health-related fitness, and disease outcomes in breast cancer survivors. Here, we present the rationale and design of the
The AMBER Study will enroll 1500 newly diagnosed, incident, stage I-IIIc breast cancer survivors in Alberta, Canada over a 5 year period. Assessments will be made at baseline (within 90 days of surgery), 1 year, and 3 years consisting of objective and self-reported measurements of physical activity, health-related fitness, blood collection, lymphedema, patient-reported outcomes, and determinants of physical activity. A final assessment at 5 years will measure patient-reported data only. The cohort members will be followed for an additional 5 years for disease outcomes.
The AMBER cohort will answer key questions related to physical activity and health-related fitness in breast cancer survivors including: (1) the independent and interactive associations of physical activity and health-related fitness with disease outcomes (e.g., recurrence, breast cancer-specific mortality, overall survival), treatment completion rates, symptoms and side effects (e.g., pain, lymphedema, fatigue, neuropathy), quality of life, and psychosocial functioning (e.g., anxiety, depression, self-esteem, happiness), (2) the determinants of physical activity and health-related fitness including demographic, medical, social cognitive, and environmental variables, (3) the mediators of any observed associations between physical activity, health-related fitness, and health outcomes including biological, functional, and psychosocial, and (4) the moderators of any observed associations including demographic, medical, and biological/disease factors. Taken together, these data will provide a comprehensive inquiry into the outcomes, determinants, mechanisms, and moderators of physical activity and health-related fitness in breast cancer survivors.