Immunohistochemical analysis of EpEx and Ep-ICD expression in papillary thyroid microcarcinoma. The representative photomicrographs show immunostaining of EpEx and Ep-ICD in PTMC. Strong membranous EpEx immunostaining was observed in the non-metastatic group (A), whereas decreased staining of membranous EpEx was observed in aggressive PTMC cases (B). The non-metastatic PTMC show predominant cytoplasmic localization of Ep-ICD and no detectable nuclear Ep-ICD staining (C), while the aggressive cases show nuclear and strong cytoplasmic Ep-ICD accumulation (D). (E) depicts the negative control. Original magnification x 400.
Kunavisarut et al. BMC Cancer 2012 12:523 doi:10.1186/1471-2407-12-523