ROC-analysis of the biomarker accuracy of VEGF family members for biopsy and resection samples. ROC-curves of VEGF-A (A), VEGF-B (B), VEGF-C (C), VEGF-D (D) and PlGF (E) are shown for biopsy and resection samples. The ROC-curves represent the sensitivity and specificity of the individual VEGF family members as colon carcinoma biomarkers. The insert gives the area under the curve (AUC), which quantifies the ability of the marker to distinguish between healthy colon and colon carcinoma. The accompanying p-value tests the null hypothesis, namely, that the AUC equals 0.50 and thus the biomarker is incompetent. The identity-line (Identity%) represents the null hypothesis. *: p < 0.05; ***: p < 0.001 calculated with the method of DeLong et al. .
Pringels et al. BMC Cancer 2012 12:515 doi:10.1186/1471-2407-12-515